Problem 11.1

a) Explain the difference between

  1. laser desorption/ionization
  2. ultrafine-metal-plus-liquid-matrix technique
  3. matrix-assisted laser desorption/ionization.

b) Why has MALDI become so successful as compared to the ultrafine-metal-plus-liquid-matrix technique?

c) What is the reason for writing a slash-sign between desorption and ionization instead of a simple space?

d) Why did MALDI cause a rapid evolution of time-of-flight analyzers?

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