Problem 12.4

a) The charged residue model rationalizes the occurrence of multiply charged ions in ESI. Calculate the theoretical m/z values of singly to quadruply charged ions as formed upon protonation of bovine insulin, C254H377N65O75S6, provided the isotopic peaks are not resolved.

b) ESI obviously possesses impressing high-mass capabilities. Nonetheless, ESI applications to polymers are rare. Why?

c) What is “charge deconvolution”?

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