Chapter 11

Matrix-Assisted Laser Desorption/Ionization

  • Ion sources for LDI and MALDI
  • Ion formation
  • MALDI matrices
  • Sample preparation
  • Applications of LDI
  • Applications of MALDI
  • MALDI-MS of synthetic polymers
  • Fingerprints by MALDI-MS
  • Carbohydrates by MALDI-MS
  • Structure elucidation of carbohydrates
  • Oligonucleotides in MALDI
  • Desorption/ionization on silicon
  • Atmospheric pressure MALDI
  • General characteristics of MALDI
  • Sample consumption and detection limit
  • Analytes for MALDI-MS
  • Types of ions in LDI and MALDI-MS
  • Mass analyzers for MALDI-MS