Problem 9.4

a) What is the difference between BE and EB magnetic sector instruments when it comes to their use for MIKES?

b) Double-focusing magnetic sector instruments can be operated in numerous scan modes for tandem MS. Some these require more than one parameter to be varied for a scan. How are those methods termed?

c) Right or wrong?

  1. B/E = const. linked scans offer good precursor ion resolution.
  2. The accurate mass of fragment ions cannot be determined when using B/E = const. linked scanning.
  3. BEBE and EBEB instruments have extensively been used for tandem MS to sequence peptides.
  4. Four sector instruments are compact and ecomonic.
  5. Tandem MS on magnetic sector instruments pioneered gas phase ion chemistry.

Answered all questions? Want to see the solutions page?