Problem 14.1

a) Explain the following acronyms related to chromatography-mass spectrometry coupling:

  • LC-MS
  • GC-MS
  • RIC
  • TIC
  • SIM
  • MID
  • HR-SIM

b) How does an EI mass spectrum change when acquired during a GC-MS run as compared to the spectrum of the same compound from a direct probe?

c) What complicates accurate mass measurements in GC-MS?

d) Which type of mass analyzer is a promising alternative to magnetic sector instruments for GC-HR-MS work?

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